America’s sandwich game is strong, with every region offering its own unique take on this classic comfort food. Although the grilled cheese (and tomato soup) might be the most well-known of all American sandwiches, these 15 sandwiches are our regional favorites and must-tries for any food lover.
1. Philly Cheesesteak – Philadelphia, PA
A legend in the sandwich world, the Philly cheesesteak features thinly sliced ribeye steak, grilled onions, and melted Cheez Whiz or provolone, all stuffed into a soft hoagie roll. Grab one at Pat’s King of Steaks or Geno’s Steaks, or for a local favorite, try John’s Roast Pork (on this list twice!).
2. Reuben – New York, NY
This deli classic is a hearty combination of corned beef, Swiss cheese, sauerkraut, and Russian dressing, all grilled between slices of rye bread. Katz’s Delicatessen serves one of the best in NYC, stacked high with tender, juicy meat.
3. Lobster Roll – Maine
A New England summer essential, the lobster roll consists of sweet, fresh lobster meat tossed in butter or mayo, served in a split-top bun. For the best versions, head to Eventide Oyster Co. in Portland or The Clam Shack in Kennebunkport.
4. Po’ Boy – New Orleans, LA
A NOLA classic, the po’ boy is a French bread sandwich stuffed with fried shrimp, oysters, roast beef, or catfish, usually topped with lettuce, tomato, and mayo. Try one at Domilise’s or Parkway Bakery & Tavern.
5. Italian Beef – Chicago, IL
This Chicago staple features thinly sliced, seasoned roast beef dipped in au jus, piled onto a long roll, and topped with spicy giardiniera or sweet peppers. Head to Al’s Beef or Johnnie’s Beef for the real deal.
6. Cuban Sandwich – Miami, FL
The Cuban sandwich is a mouthwatering combination of roast pork, ham, Swiss cheese, pickles, and mustard, all pressed in crispy Cuban bread. For authenticity, visit Versailles or Sanguich de Miami.
7. Roast Pork Sandwich – Philadelphia, PA
Philly’s other great sandwich, the roast pork sandwich, is packed with garlic-seasoned pork, sharp provolone, and sautéed broccoli rabe on a hoagie roll. John’s Roast Pork and DiNic’s (which won the best sandwich in America once) serve the best versions.
8. Muffuletta – New Orleans, LA
A Sicilian-inspired sandwich, the muffuletta is stacked with salami, mortadella, ham, provolone, and olive salad on a round sesame loaf. Grab one at Central Grocery, the birthplace of this Louisiana classic.
9. Primanti Bros. Sandwich – Pittsburgh, PA
A masterpiece, this thick sandwich layers deli meat, French fries, coleslaw, and tomato between slices of Italian bread. Primanti Bros. has been serving it up since the 1930s.
10. BBQ Brisket Sandwich – Texas
Slow-smoked Texas brisket, sliced or chopped, is piled onto a soft bun with barbecue sauce, pickles, and onions. Franklin Barbecue in Austin serves a legendary version with melt-in-your-mouth meat.
11. Hot Brown – Louisville, KY
An open-faced sandwich, the Hot Brown consists of roast turkey, bacon, and Mornay sauce, broiled until golden and bubbly. The best place to try one is The Brown Hotel, where it was invented.
12. Fried Pork Tenderloin Sandwich – Indiana
A Midwestern favorite, this sandwich features a massive breaded and fried pork tenderloin cutlet that’s bigger than the bun. Try it at Nick’s Kitchen in Huntington, IN.
13. Bánh Mì – Houston, TX
Vietnamese flavors meet French influence in the bánh mì, a baguette sandwich filled with grilled pork, pickled vegetables, cilantro, and spicy mayo. Houston’s Les Givral’s and Roostar serve some of the best.
14. Fried Bologna Sandwich – Ohio & Midwest
A favorite featuring thick-cut fried bologna, melty cheese, and mustard on white bread. For an elevated take, check out The Grumpy Pig in Columbus, OH.
15. French Dip – Los Angeles, CA
Served with a side of au jus for dipping, this roast beef sandwich on a French roll is a West Coast favorite. Philippe The Original and Cole’s both claim to have invented it—try both and decide for yourself!
These 15 sandwiches are the best of the best, celebrating flavors from across the USA. Whether you crave a cheesy Philly cheesesteak, a crispy fried po’ boy, or a smoky Texas brisket sandwich, these legendary bites deserve a spot on your must-try list.
Best BBQ Place in the USA
Barbecue in the USA is more than just a method of cooking—it’s a regional art form. From smoky brisket in Texas to tender ribs in Memphis, every state brings its own flavor to the table. Here are 20 of the best BBQ joints across the country, each offering a unique take on the smoky, savory cuisine that Americans love.